Table 5 Univariate and multivariate analysis of prognostic factors for overall survival
Overall survival | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
HR (95% CI) | p value | HR (95% CI) | p value | |
Age (≤ 65 vs >65) | 1.31 (0.93-1.87) | 0.12 | ||
Sex (male vs female) | 1.37 (0.99-1.91) | 0.06 | ||
Primary Tumor | NA | 0.01 | NA | 0.017 |
Site | NA | 0.60 | ||
(subtentorial vs supratentorial) | 0.72 (0.40-1.29) | 0.28 | ||
(supratentorial and subtentorial vs supratentorial ) | 1.40 (0.96-2.05) | 0.75 | ||
(supratentorial and subtentorial vs subtentorial | 1.93 (1.1-2.53) | 0.03 | ||
Neurologic Symptom (yes vs no) | 1.51 (1.06-2.14) | 0.02 | 0.66 (0.44-0.99) | 0.046 |
RPA-RTOG classes | NA | 0.21 | ||
(2 vs 1) | 1.18 (0.77-1.70) | 0.43 | ||
(3 vs 1) | 1.78 (0.93-3.43) | 0.08 | ||
(2 vs 3) | 0.66 (0.36-1.19) | 0.16 | ||
Type of treatment | NA | < 0.0001 | 0.02 | |
(CT vs WBRT) | 1.05 (0.72-1.53) | 0.78 | 1.16 (0.76-1.76) | 0.47 |
(Surgery/SRS vs WBRT) | 0.37 (0.23-0.61) | < 0.0001 | 0.47 (0.26-0.87) | 0.02 |
(Surgery/SRS vs CT) | 0.35 (0.21-0.60) | < 0.0001 | 0.41 (0.21-0.77) | 0.006 |
Number of brain metastases | NA | < 0.0001 | 0.013 | |
(2-3 vs 1) | 1.39 (0.86-2.24) | 0.17 | 1.36 (0.79-2.34) | 0.25 |
(>3 vs 1) | 2.20 (1.48-3.27) | < 0.0001 | 2.04 (1.26-3.33) | 0.004 |
(2-3 vs > 3) | 0.63 (0.41-0.96) | 0.03 | 0.66 (0.41-1.07) | 0.10 |