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Table 5 Univariate and multivariate analysis of prognostic factors for overall survival

From: Brain metastases from solid tumors: disease outcome according to type of treatment and therapeutic resources of the treating center

Overall survival Univariate Analysis Multivariate Analysis
  HR (95% CI) p value HR (95% CI) p value
Age (≤ 65 vs >65) 1.31 (0.93-1.87) 0.12   
Sex (male vs female) 1.37 (0.99-1.91) 0.06   
Primary Tumor NA 0.01 NA 0.017
Site NA 0.60   
(subtentorial vs supratentorial) 0.72 (0.40-1.29) 0.28   
(supratentorial and subtentorial vs
supratentorial )
1.40 (0.96-2.05) 0.75   
(supratentorial and subtentorial vs
subtentorial
1.93 (1.1-2.53) 0.03   
Neurologic Symptom (yes vs no) 1.51 (1.06-2.14) 0.02 0.66 (0.44-0.99) 0.046
RPA-RTOG classes NA 0.21   
(2 vs 1) 1.18 (0.77-1.70) 0.43   
(3 vs 1) 1.78 (0.93-3.43) 0.08   
(2 vs 3) 0.66 (0.36-1.19) 0.16   
Type of treatment NA < 0.0001   0.02
(CT vs WBRT) 1.05 (0.72-1.53) 0.78 1.16 (0.76-1.76) 0.47
(Surgery/SRS vs WBRT) 0.37 (0.23-0.61) < 0.0001 0.47 (0.26-0.87) 0.02
(Surgery/SRS vs CT) 0.35 (0.21-0.60) < 0.0001 0.41 (0.21-0.77) 0.006
Number of brain metastases NA < 0.0001   0.013
(2-3 vs 1) 1.39 (0.86-2.24) 0.17 1.36 (0.79-2.34) 0.25
(>3 vs 1) 2.20 (1.48-3.27) < 0.0001 2.04 (1.26-3.33) 0.004
(2-3 vs > 3) 0.63 (0.41-0.96) 0.03 0.66 (0.41-1.07) 0.10