α-Amylase effects on cell growth in F344 and Lewis cells after treatment for 2 days with 5 and 50 U/ml. The mean α-amylase effect is shown as change in total cell number compared to the water-treated control cells (percent change; mean and SEM). Results from four to five different experiments were summarized and evaluated together for F344 and Lewis cells (n = 29-35 wells per group). Numbers of cells were significantly decreased after α-amylase treatment (50 U/ml) indicating antiproliferative effects. Lewis cells were significantly more sensitive towards α-amylase than F344 following incubation with both 5 U/ml and 50 U/ml. Statistics: One-way-ANOVA and Bonferroni for selected pairs: significant differences between controls and α-amylase are indicated by asterisk (p < 0.05); Two-way-ANOVA and Bonferroni: significant differences between F344 vs. Lewis and 5 U/ml vs. 50 U/ml are indicated by rhomb (p < 0.05).