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Figure 4 | Journal of Experimental & Clinical Cancer Research

Figure 4

From: Compound Kushen Injection suppresses human breast cancer stem-like cells by down-regulating the canonical Wnt/β-catenin pathway

Figure 4

SP cells were more tumorigenic. (A) Tumor volumes (mean ± SEM) were plotted for 1 × 103 cells of each population (SP, non-SP) injected (n = 6 per group). Tumors derived from SP were larger than those from non-SP. (B) Representative tumors due to injection of SP cells (1 × 104 cells, 1 × 103 cells) compared with non-SP injection (1 × 104 cells, 1 × 103 cells). (C) A representative tumor in a mouse specimen at the SP injection (1 × 103 cells) site, but not at the non-SP injection (1 × 103 cells) site. Histology from the SP injection site ((D), Original magnification, ×200) contained malignant cells, whereas the non-SP injection site ((E), Original magnification, ×200) revealed only normal mammary tissue.

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