Figure 1From: LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett's Esophagus?Immunohistochemical staining of LgR5 (membranous staining pattern, brown) in normal colon tissue. Normal colon mucosa (asterisk) showed the typical staining pattern as they stained the well-described putative colon mucosa stem cells, located at the basis of the crypts, or the transit amplifying zone, which are regarded to resemble the stem cell niche (arrows). Original magnification, × 200 (a) and × 400 (b).Back to article page