Table 1 Clinicopathological characteristics of the EAC study population with BE
| Characteristics |
Patients (n = 41) |
LgR5 Barrett's esophagus* | p-value |
LgR5 Barrett's EAC | p-value | ||
|---|---|---|---|---|---|---|---|
| low | high | low | high | ||||
| Age (y) | .100 | .051 | |||||
| <66 | 21 (51%) | 10 (48%) | 11 (52%) | 4 (19%) | 17 (81%) | ||
| ≥66 | 20 (49%) | 4 (20%) | 16 (80%) | 10 (50%) | 10 (50%) | ||
| Gender | .074 | .673 | |||||
| Male | 34 (83%) | 14 (41%) | 20 (59%) | 11 (32%) | 23 (68%) | ||
| Female | 7 (17%) | 0 (0%) | 7 (100%) | 3 (43%) | 4 (57%) | ||
| Histological Grading | .305a | .083a | |||||
| G1 | 11 (27%) | 6 (55%) | 5 (45%) | 6 (55%) | 5 (45%) | ||
| G2 | 16 (39%) | 5 (31%) | 11 (69%) | 6 (37%) | 10 (63%) | ||
| G3/4 | 14(34%) | 3 (21%) | 11 (79%) | 2 (14%) | 12 (86%) | ||
| Depth of invasion | .481b | .155b | |||||
| pT1 | 10 (24%) | 4 (40%) | 6 (60%) | 6 (60%) | 4 (40%) | ||
| pT2 | 18 (44%) | 7 (39%) | 11 (61%) | 6 (33%) | 12 (67%) | ||
| pT3 | 6 (15%) | 1 (17%) | 5 (83%) | 1 (17%) | 5 (83%) | ||
| pT4 | 7 (17%) | 2 (28%) | 5 (72%) | 1 (14%) | 6 (86%) | ||
| Lymph node metastases | .001 | .0154 | |||||
| pN0 | 15 (37%) | 10 (67%) | 5 (33%) | 9 (60%) | 6 (40%) | ||
| pN1-3 | 26 (63%) | 4 (15%) | 22 (85%) | 5 (19%) | 21 (81%) | ||
| UICC stage | .481c | .155c | |||||
| UICC I | 9 (22%) | 4 (44%) | 5 (56%) | 2 (22%) | 4 (78%) | ||
| UICC II | 19 (46%) | 7 (37%) | 12 (63%) | 7 (37%) | 12 (63%) | ||
| UICC III | 13 (31%) | 3 (23%) | 10 (77%) | 5 (15%) | 11 (85%) | ||
| UICC IV | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | ||
| Median OS (m) | 42 m | 32 (n = 14) | 24 (n = 27) | 33 (n = 14) | 28 (n = 27) | ||