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Table 2 Clinicopathological characteristics of the EAC study population (with and without BE)

From: LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett's Esophagus?

Characteristics Patients
(n = 60)
LgR5
EAC
p-value
   low high  
Age (y)     .069
<66 30 (50%) 10 (33%) 20 (67%)  
≥66 30 (50%) 18 (60%) 12 (40%)  
Gender     1.00
Male 52 (87%) 24 (46%) 28 (34%)  
Female 8 (13%) 4 (50%) 4 (50%)  
Histological classification     .577a
G1 17 (28%) 11 (65%) 6 (35%)  
G2 22 (37%) 11 (50%) 11 (50%)  
G3/4 21 (33%) 6 (29%) 15 (71%)  
Depth of invasion     .259b
pT1 16 (27%) 11 (69%) 5 (31%)  
pT2 26 (43%) 11 (42%) 15 (58%)  
pT3 10 (17%) 4 (40%) 6 (60%)  
pT4 8 (13%) 2 (25%) 6 (75%)  
Lymph nodes metastasis     .007
pN0 23 (38%) 16 (70%) 7 (30%)  
pN1-3 37 (62%) 12 (32%) 25 (68%)  
UICC stage     .573c
UICC I 14 (23%) 10 (71%) 4 (29%)  
UICC II 28 (47%) 11 (39%) 17 (61%)  
UICC III 18 (30%) 7 (39%) 11 (61%)  
UICC IV 0 (0%) 0 (0%) 0 (0%)  
Median OS (m) 43 m 32 (n = 28) 24 (n = 32)  
  1. Abbrevations: EAC, esophageal adenocarcinomas; BE, Barrett metaplasia; y, years; G, grading; UICC, International Union against Cancer; R, residual tumor; OS, overall survival; m, months.
  2. aG1/2 vs. GT3/4; bpT1/2 vs. pT3/4; cUICC I/II vs. UICC III/IV