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Table 2 Clinicopathological characteristics of the EAC study population (with and without BE)

From: LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett's Esophagus?

Characteristics

Patients

(n = 60)

LgR5

EAC

p-value

  

low

high

 

Age (y)

   

.069

<66

30 (50%)

10 (33%)

20 (67%)

 

≥66

30 (50%)

18 (60%)

12 (40%)

 

Gender

   

1.00

Male

52 (87%)

24 (46%)

28 (34%)

 

Female

8 (13%)

4 (50%)

4 (50%)

 

Histological classification

   

.577a

G1

17 (28%)

11 (65%)

6 (35%)

 

G2

22 (37%)

11 (50%)

11 (50%)

 

G3/4

21 (33%)

6 (29%)

15 (71%)

 

Depth of invasion

   

.259b

pT1

16 (27%)

11 (69%)

5 (31%)

 

pT2

26 (43%)

11 (42%)

15 (58%)

 

pT3

10 (17%)

4 (40%)

6 (60%)

 

pT4

8 (13%)

2 (25%)

6 (75%)

 

Lymph nodes metastasis

   

.007

pN0

23 (38%)

16 (70%)

7 (30%)

 

pN1-3

37 (62%)

12 (32%)

25 (68%)

 

UICC stage

   

.573c

UICC I

14 (23%)

10 (71%)

4 (29%)

 

UICC II

28 (47%)

11 (39%)

17 (61%)

 

UICC III

18 (30%)

7 (39%)

11 (61%)

 

UICC IV

0 (0%)

0 (0%)

0 (0%)

 

Median OS (m)

43 m

32 (n = 28)

24 (n = 32)

 
  1. Abbrevations: EAC, esophageal adenocarcinomas; BE, Barrett metaplasia; y, years; G, grading; UICC, International Union against Cancer; R, residual tumor; OS, overall survival; m, months.
  2. aG1/2 vs. GT3/4; bpT1/2 vs. pT3/4; cUICC I/II vs. UICC III/IV