TY - JOUR AU - Lindquist, S. AU - Craig, E. A. PY - 1988 DA - 1988// TI - The heat-shock proteins JO - Annu Rev Genet VL - 22 UR - https://doi.org/10.1146/annurev.ge.22.120188.003215 DO - 10.1146/annurev.ge.22.120188.003215 ID - Lindquist1988 ER - TY - JOUR AU - Clarke, A. R. PY - 1996 DA - 1996// TI - Molecular chaperones in protein folding and translocation JO - Curr Opin Struct Biol VL - 6 UR - https://doi.org/10.1016/S0959-440X(96)80093-5 DO - 10.1016/S0959-440X(96)80093-5 ID - Clarke1996 ER - TY - JOUR AU - Giaginis, C. AU - Daskalopoulou, S. S. AU - Vgenopoulou, S. AU - Sfiniadakis, I. AU - Kouraklis, G. AU - Theocharis, S. E. PY - 2009 DA - 2009// TI - Heat Shock Protein-27, -60 and -90 expression in gastric cancer: association with clinicopathological variables and patient survival JO - BMC Gastroenterology VL - 9 UR - https://doi.org/10.1186/1471-230X-9-14 DO - 10.1186/1471-230X-9-14 ID - Giaginis2009 ER - TY - JOUR AU - Ogata, M. AU - Naito, Z. AU - Tanaka, S. AU - Moriyama, Y. AU - Asano, G. PY - 2000 DA - 2000// TI - Overexpression and localization of heat shock proteins mRNA in pancreatic carcinoma JO - J Nippon Med Sch VL - 67 UR - https://doi.org/10.1272/jnms.67.177 DO - 10.1272/jnms.67.177 ID - Ogata2000 ER - TY - JOUR AU - Srivastava, P. K. AU - Deleo, A. B. AU - Old, L. J. PY - 1986 DA - 1986// TI - Tumor rejection antigens of chemically induced sarcomas of inbred mice JO - Proc Natl Acad Sci USA VL - 83 UR - https://doi.org/10.1073/pnas.83.10.3407 DO - 10.1073/pnas.83.10.3407 ID - Srivastava1986 ER - TY - JOUR AU - Rivoltini, L. AU - Castelli, C. AU - Carrabba, M. AU - Mazzaferro, V. AU - Pilla, L. AU - Huber, V. AU - Coppa, J. AU - Gallino, G. AU - Scheibenbogen, C. AU - Squarcina, P. AU - Cova, A. AU - Camerini, R. AU - Lewis, J. J. AU - Srivastava, P. K. AU - Parmiani, G. PY - 2003 DA - 2003// TI - Human tumor-derived heat shock protein 96 mediates in vitro activation and in vivo expansion of melanoma- and colon carcinoma-specific T cells JO - J Immunol VL - 171 UR - https://doi.org/10.4049/jimmunol.171.7.3467 DO - 10.4049/jimmunol.171.7.3467 ID - Rivoltini2003 ER - TY - JOUR AU - Janetzki, S. AU - Blachere, N. E. AU - Srivastava, P. K. PY - 1998 DA - 1998// TI - Generation of tumor-specific cytotoxic T lymphocytes and memory T cells by immunization with tumor-derived heat shock protein gp96 JO - J Immuno VL - 21 ID - Janetzki1998 ER - TY - JOUR AU - Singh-Jasuja, H. AU - Scherer, H. U. AU - Hilf, N. AU - Arnold-Schild, D. AU - Rammensee, H. G. AU - Toes, R. E. AU - Schild, H. PY - 2000 DA - 2000// TI - The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor JO - Eur J Immunol VL - 30 UR - https://doi.org/3.0.CO;2-0 DO - 3.0.CO;2-0 ID - Singh-Jasuja2000 ER - TY - JOUR AU - IChu, N. R. AU - Wu, H. B. AU - Wu, T. C. AU - Boux, L. J. AU - Mizzen, L. A. AU - Siegel, M. PY - 2000 DA - 2000// TI - Immunotherapy of a human papillomavirus(HPV) type 16 E7-expressing tumor by administration of fusion HPV16 E7 JO - Clin Exp Immunol VL - 121 UR - https://doi.org/10.1046/j.1365-2249.2000.01293.x DO - 10.1046/j.1365-2249.2000.01293.x ID - IChu2000 ER - TY - JOUR AU - Ciupitu Anne-Marie, T. AU - Petersson, M. AU - Kono, K. AU - Charo, J. AU - Kiessling, R. PY - 2002 DA - 2002// TI - Imunization with heat shock protein 70 from methylcholanthrene-induced sarcomas induces tumor protection correlating with in vitro T cell responses JO - Cancer Immuno Immunother VL - 51 UR - https://doi.org/10.1007/s00262-002-0263-9 DO - 10.1007/s00262-002-0263-9 ID - Ciupitu Anne-Marie2002 ER - TY - JOUR AU - Tamura, Y. AU - Peng, P. AU - Liu, K. AU - Daou, M. AU - Srivastava, P. K. PY - 1997 DA - 1997// TI - Immunotherapy of tumor with autologous tumor derived heat shock protein preparations JO - Science VL - 278 ID - Tamura1997 ER - TY - JOUR AU - Wang, X. Y. AU - manjili, M. H. AU - Park, J. AU - Chen, X. AU - Repasky, E. AU - Subjeck, J. R. PY - 2004 DA - 2004// TI - Development of cancer vaccines using autologous and recombinant high molecular weight stress proteins JO - Methods VL - 32 UR - https://doi.org/10.1016/S1046-2023(03)00181-6 DO - 10.1016/S1046-2023(03)00181-6 ID - Wang2004 ER - TY - JOUR AU - Segal, B. H. AU - Wang, X. -. Y. AU - Dennis, C. G. AU - Youn, R. AU - Repasky, E. A. AU - Manjili, M. H. AU - Subjeck, J. R. PY - 2006 DA - 2006// TI - Heat shock proteins as vaccine adjuvants in infections and cancer JO - Drug Discovery Today VL - 11 UR - https://doi.org/10.1016/j.drudis.2006.04.016 DO - 10.1016/j.drudis.2006.04.016 ID - Segal2006 ER - TY - JOUR AU - Gullo, C. A. AU - Teoh, G. PY - 2004 DA - 2004// TI - Heat shock proteins: to present or not, that is the question JO - Immunology Letters VL - 9491-2 UR - https://doi.org/10.1016/j.imlet.2004.04.002 DO - 10.1016/j.imlet.2004.04.002 ID - Gullo2004 ER - TY - JOUR AU - Gastpar, R. AU - Gehrmann, M. AU - Bausero, M. A. AU - Asea, A. AU - Gross, C. AU - Schroeder, J. A. AU - Multhoff, G. PY - 2005 DA - 2005// TI - Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells JO - Cancer Res VL - 65 UR - https://doi.org/10.1158/0008-5472.CAN-04-3804 DO - 10.1158/0008-5472.CAN-04-3804 ID - Gastpar2005 ER - TY - JOUR AU - Pilla, L. AU - Squarcina, P. AU - Coppa, J. AU - Mazzaferro, V. AU - Huber, V. AU - Pende, D. AU - Maccalli, C. AU - Sovena, G. AU - Mariani, L. AU - Castelli, C. AU - Parmiani, G. AU - Rivoltini, L. PY - 2005 DA - 2005// TI - Natural killer and NK-Like T-cell activation in colorectal carcinoma patients treated with autologous tumor-derived heat shock protein 96 JO - Cancer Res VL - 65 UR - https://doi.org/10.1158/0008-5472.CAN-04-3493 DO - 10.1158/0008-5472.CAN-04-3493 ID - Pilla2005 ER - TY - JOUR AU - Srivastava PY - 2002 DA - 2002// TI - Roles of heat-shock proteins in innate and adaptive immunity JO - Nat Rev Immunol VL - 2 UR - https://doi.org/10.1038/nri749 DO - 10.1038/nri749 ID - Srivastava2002 ER - TY - JOUR AU - Hoos, A. x. e. l. AU - Levey Daniel, L. PY - 2003 DA - 2003// TI - Vaccination with heat shock protein-peptide complexes: from basic science to clinical applications JO - Expert Review of Vaccines VL - 2 UR - https://doi.org/10.1586/14760584.2.3.369 DO - 10.1586/14760584.2.3.369 ID - Hoos2003 ER - TY - JOUR AU - Testori, A. AU - Richards, J. AU - Whitman, E. AU - Mann, G. B. AU - Lutzky, J. AU - Camacho, L. AU - Parmiani, G. AU - Tosti, G. AU - Kirkwood, J. M. AU - Hoos, A. AU - Yuh, L. AU - Gupta, R. AU - Srivastava, P. K. PY - 2008 DA - 2008// TI - Phase III comparison of vitespen, an autologous tumor-derived heat shock protein gp96 peptide complex vaccine, with physician's choice of treatment for stage IV melanoma: the C-100-21 Study Group JO - J Clin Oncol VL - 26 UR - https://doi.org/10.1200/JCO.2007.11.9941 DO - 10.1200/JCO.2007.11.9941 ID - Testori2008 ER - TY - JOUR AU - Eton, O. AU - Ross Merrick, I. AU - East, M. J. AU - Mansfield, P. F. AU - Papadopoulos, N. AU - Ellerhorst, J. A. AU - Bedikian, A. Y. AU - Lee, J. E. PY - 2010 DA - 2010// TI - Autologous tumor-derived heat-shock protein peptide complex-96 (HSPPC-96) in patients with metastatic melanoma JO - Journal of Translational Medicine VL - 8 UR - https://doi.org/10.1186/1479-5876-8-9 DO - 10.1186/1479-5876-8-9 ID - Eton2010 ER - TY - JOUR AU - Wood, C. AU - Srivastava, P. AU - Bukowski, R. AU - Lacombe, L. AU - Gorelov, A. I. AU - Gorelov, S. AU - Mulders, P. AU - Zielinski, H. AU - Hoos, A. AU - Teofilovici, F. AU - Isakov, L. AU - Flanigan, R. AU - Figlin, R. AU - Gupta, R. AU - Escudier, B. PY - 2008 DA - 2008// TI - An adjuvant autologous therapeutic vaccine (HSPPC-96; vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma: a multicentre, open-label, randomised phase III trial JO - Lancet VL - 372 UR - https://doi.org/10.1016/S0140-6736(08)60697-2 DO - 10.1016/S0140-6736(08)60697-2 ID - Wood2008 ER - TY - JOUR AU - Mazzaferro, V. AU - Coppa, J. AU - Carrabba, M. G. AU - Rivoltini, L. AU - Schiavo, M. AU - Regalia, E. AU - Mariani, L. AU - Camerini, T. AU - Marchianò, A. AU - Andreola, S. AU - Camerini, R. AU - Corsi, M. AU - Lewis, J. J. AU - Srivastava, P. K. AU - Parmiani, G. PY - 2003 DA - 2003// TI - Vaccination with autologous tumor-derived heat-shock protein gp96 after liver resection for metastatic colorectal cancer JO - Clin Cancer Res VL - 9 ID - Mazzaferro2003 ER - TY - JOUR AU - Oki, Y. AU - McLaughlin, P. AU - Fayad, L. E. AU - Pro, B. AU - Mansfield, P. F. AU - Clayman, G. L. AU - Medeiros, L. J. AU - Kwak, L. W. AU - Srivastava, P. K. AU - Younes, A. PY - 2007 DA - 2007// TI - Experience with heat shock protein-peptide complex 96 vaccine therapy in patients with indolent non-Hodgkin lymphoma JO - Cancer VL - 109 UR - https://doi.org/10.1002/cncr.22389 DO - 10.1002/cncr.22389 ID - Oki2007 ER - TY - JOUR AU - Gong, J. AU - Zhang, Y. AU - Durfee, J. AU - Weng, D. AU - Liu, C. AU - Koido, S. AU - Song, B. AU - Apostolopoulos, V. AU - Calderwood, S. K. PY - 2010 DA - 2010// TI - A Heat Shock Protein 70-Based Vaccine with Enhanced Immunogenicity for Clinical Use JO - J Immunology VL - 184 UR - https://doi.org/10.4049/jimmunol.0902255 DO - 10.4049/jimmunol.0902255 ID - Gong2010 ER - TY - JOUR AU - Graner, M. AU - Raymond, A. PY - 2000 DA - 2000// TI - Tumor-derived multiple chaperone enrichment by free-solution isoelectric focusing yields potent antitumor vaccines JO - Cancer Immunol Immunother VL - 49 UR - https://doi.org/10.1007/s002620000138 DO - 10.1007/s002620000138 ID - Graner2000 ER - TY - JOUR AU - Tang, Y. u. AU - Cui, X. M. AU - Yuan, M. AU - Lu, S. B. PY - 2006 DA - 2006// TI - Primary experimental observation on mice sarcoma with heat shock protein/peptides complex for immunotherapy JO - Chin J Cancer Prev Treat VL - 13 ID - Tang2006 ER - TY - JOUR AU - Cui, X. M. AU - Yuan, M. AU - Tang, Y. AU - Lu, S. B. PY - 2006 DA - 2006// TI - Therapeutic effects of mixed heat shock protein/peptides on mice sarcoma JO - ZhongHua ShiYan WaiKe ZaZhi VL - 23 ID - Cui2006 ER - TY - JOUR AU - Pilla, L. AU - Patuzzo, R. AU - Rivoltini, L. AU - Maio, M. AU - Pennacchioli, E. AU - Lamaj, E. AU - Maurichi, A. AU - Massarut, S. AU - Marchianò, A. AU - Santantonio, C. AU - Tosi, D. AU - Arienti, F. AU - Cova, A. AU - Sovena, G. AU - Piris, A. AU - Nonaka, D. AU - Bersani, I. AU - Di Florio, A. AU - Luigi, M. AU - Srivastava, P. K. AU - Hoos, A. AU - Santinami, M. AU - Parmiani, G. PY - 2006 DA - 2006// TI - A phase II trial of vaccination with autologous, tumor-derived heat-shock protein peptide complexes gp96, in combination with GM-CSF and interferon-alpha in metastatic melanoma patients JO - Cancer Immunol Immunother VL - 55 UR - https://doi.org/10.1007/s00262-005-0084-8 DO - 10.1007/s00262-005-0084-8 ID - Pilla2006 ER - TY - JOUR AU - Tsung, K. L. AU - Dolan, J. P. AU - Tsung, L. Y. PY - 2002 DA - 2002// TI - Macrophages as effective cells in interleukine 12 induced T cell-dependent tumor rejection JO - Cancer Res VL - 62 ID - Tsung2002 ER - TY - JOUR AU - Colombo, M. P. AU - Trinchieri, G. PY - 2002 DA - 2002// TI - Interleukin-12 in anti-tumor immunity and immunotherapy JO - Cytokine & Growth Factor Reviews VL - 13 UR - https://doi.org/10.1016/S1359-6101(01)00032-6 DO - 10.1016/S1359-6101(01)00032-6 ID - Colombo2002 ER - TY - JOUR AU - Gao, J. -. Q. AU - Sugita, T. AU - Kanagawa, N. AU - Iida, K. AU - Eto, Y. AU - Motomura, Y. AU - Mizuguchi, H. AU - Tsutsumi, Y. AU - Hayakawa, T. AU - Mayumi, T. AU - Nakagawa, S. PY - 2005 DA - 2005// TI - A single intratumoral injection of a fiber-mutant adenoviral vector encoding interleukin 12 induces remarkable anti-tumor and anti-metastatic activity in mice with Meth-A fibrosarcoma JO - Biochemical and Biophysical Research Communications VL - 328 UR - https://doi.org/10.1016/j.bbrc.2005.01.061 DO - 10.1016/j.bbrc.2005.01.061 ID - Gao2005 ER - TY - JOUR AU - Wigginton, J. M. AU - Gruys, E. AU - Geiselhart, L. AU - Subleski, J. AU - Komschlies, K. L. AU - Park, J. o. n. g. -. W. AU - Wiltrout, T. A. AU - Nagashima, K. AU - Back, T. C. AU - Wiltrout, R. H. PY - 2001 DA - 2001// TI - IFN-γ and Fas/FasL are required for the antitumor and antiangiogenic effects of IL-12/pulse IL-2 therapy JO - J Clin Invest VL - 108 UR - https://doi.org/10.1172/JCI200110128 DO - 10.1172/JCI200110128 ID - Wigginton2001 ER - TY - JOUR AU - Hop N, L. e. AU - Natalie C, L. e. e. AU - Kangla, T. s. u. n. g. AU - Jeffrey A, N. o. r. t. o. n. PY - 2001 DA - 2001// TI - Pre-Existing Tumor-Sensitized T Cells are essential for Eradication of Established Tumors by IL-12 and Cyclophosphamide Plus IL-12 JO - Journal of Immunology VL - 167 UR - https://doi.org/10.4049/jimmunol.167.12.6765 DO - 10.4049/jimmunol.167.12.6765 ID - Hop N2001 ER - TY - JOUR AU - Nagaraj, S. AU - Gabrilovich, D. I. PY - 2008 DA - 2008// TI - Tumor escape mechanism governed by myeloid-derived suppressor cells JO - Cancer Res VL - 68 UR - https://doi.org/10.1158/0008-5472.CAN-07-6229 DO - 10.1158/0008-5472.CAN-07-6229 ID - Nagaraj2008 ER - TY - JOUR AU - Sica, A. AU - Bronte, V. PY - 2007 DA - 2007// TI - Altered macrophage differentiation and immune dysfunction in tumor development JO - J Clin Invest VL - 117 UR - https://doi.org/10.1172/JCI31422 DO - 10.1172/JCI31422 ID - Sica2007 ER - TY - JOUR AU - Younes, A. AU - Pro, B. AU - Robertson, M. J. AU - Flinn, I. W. AU - Romaguera, J. E. AU - Hagemeister, F. AU - Dang, N. H. AU - Fiumara, P. AU - Loyer, E. M. AU - Cabanillas, F. F. AU - McLaughlin, P. W. AU - Rodriguez, M. A. AU - Samaniego, F. PY - 2004 DA - 2004// TI - Phase II clinical trial of interleukin-12 in patients with relapsed and refractory non-Hodgkin's lymphoma and Hodgkin's disease JO - Clin Cancer Res VL - 10 UR - https://doi.org/10.1158/1078-0432.CCR-04-0540 DO - 10.1158/1078-0432.CCR-04-0540 ID - Younes2004 ER - TY - JOUR AU - Wadler, S. AU - Levy, D. AU - Frederickson, H. L. AU - Falkson, C. I. AU - Wang, Y. AU - Weller, E. AU - Burk, R. AU - Ho, G. AU - Kadish, A. S. PY - 2004 DA - 2004// TI - A phase II trial of interleukin-12 in patients with advanced cervical cancer: clinical and immunologic correlates. Eastern Cooperative Oncology Group study E1E96 JO - Gynecol Oncol VL - 92 UR - https://doi.org/10.1016/j.ygyno.2003.12.022 DO - 10.1016/j.ygyno.2003.12.022 ID - Wadler2004 ER - TY - JOUR AU - Brode, S. AU - Raine, T. AU - Cooke, A. PY - 2006 DA - 2006// TI - Cyclophosphamide-Induced Type-1 Diabetes in the NOD Mouse Is Associated with a Reduction of CD4+CD25+Foxp3+ Regulatory T Cells JO - The Journal of Immunology VL - 177 UR - https://doi.org/10.4049/jimmunol.177.10.6603 DO - 10.4049/jimmunol.177.10.6603 ID - Brode2006 ER - TY - CHAP AU - Di Paolo Nelson, C. AU - Tuve, S. AU - Ni, S. AU - Hellström, K. E. AU - Hellström, I. AU - Lieber, A. PY - 2006 DA - 2006// BT - Effect of Adenovirus-Mediated Heat Shock Protein Expression and Oncolysis in Combination with Low-Dose Cyclophosphamide Treatment on Antitumor Immune Responses Cancer Research ID - Di Paolo Nelson2006 ER - TY - JOUR AU - Taieb, J. AU - Chaput, N. AU - Schartz, N. AU - Roux, S. AU - Novault, S. AU - Ménard, C. AU - Ghiringhelli, F. AU - Terme, M. AU - Carpentier, A. F. AU - Darrasse-Jèze, G. AU - Lemonnier, F. AU - Zitvogel, L. PY - 2006 DA - 2006// TI - Chemoimmunotherapy of tumors: cyclophosphamide synergizes with exosome based vaccines JO - J Immunol VL - 176 UR - https://doi.org/10.4049/jimmunol.176.5.2722 DO - 10.4049/jimmunol.176.5.2722 ID - Taieb2006 ER - TY - JOUR AU - Morini, M. AU - Albini, A. AU - Lorusso, G. AU - Moelling, K. AU - Lu, B. AU - Cilli, M. AU - Ferrini, S. AU - Noonan, D. M. PY - 2004 DA - 2004// TI - Prevention of angiogenesis by naked DNA IL-12 gene transfer: angioprevention by immunogene therapy JO - Gene Therapy VL - 11 UR - https://doi.org/10.1038/sj.gt.3302175 DO - 10.1038/sj.gt.3302175 ID - Morini2004 ER - TY - JOUR AU - Motoyoshi, Y. AU - Kaminoda, K. AU - Saitoh, O. PY - 2006 DA - 2006// TI - Different mechanisms for anti-tumor effects of low- and high-dose cyclophosphamide JO - Oncol Rep VL - 16 ID - Motoyoshi2006 ER - TY - JOUR AU - François, G. AU - Nicolas, L. AU - Elise, S. AU - Parcellier, A. AU - Dominique, C. AU - Carmen, G. AU - Bruno, C. AU - François, M. PY - 2004 DA - 2004// TI - CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative JO - Eur J Immunol VL - 34 UR - https://doi.org/10.1002/eji.200324181 DO - 10.1002/eji.200324181 ID - François2004 ER - TY - JOUR AU - Salem, M. L. AU - Kadima, A. N. AU - EL-Naggar, S. A. PY - 2007 DA - 2007// TI - Defining the ability of cytophosphamide preconditioning to enhance the antigen-specific CD8+ T-cell response to peptide vaccination: Creation of a beneficial host microenvironment involving type 1 IFNs and myeloid cells JO - J Immunother VL - 30 UR - https://doi.org/10.1097/01.cji.0000211311.28739.e3 DO - 10.1097/01.cji.0000211311.28739.e3 ID - Salem2007 ER - TY - JOUR AU - Breloer, M. AU - Dorner, B. AU - More, S. H. PY - 2001 DA - 2001// TI - Heat shock proteins as "danger signals": eukaryotic Hsp60 enhances and accelerates antigen-specific IFN-gamma production in T cells JO - Eur J Immunol VL - 31 UR - https://doi.org/3.0.CO;2-H DO - 3.0.CO;2-H ID - Breloer2001 ER - TY - JOUR AU - Castelli, R. L. AU - Carrabba, C. AU - Mazzaferro, M. AU - Pilla, V. AU - Huber, L. AU - Coppa, V. AU - Parmiani, J. AU - Giorgio, P. PY - 2003 DA - 2003// TI - Human tumor-derived heat shock protein 96 mediates in vitro activation and in vivo expansion of melanoma- and colon carcinoma-specific T cells JO - J Immunol VL - 171 UR - https://doi.org/10.4049/jimmunol.171.7.3467 DO - 10.4049/jimmunol.171.7.3467 ID - Castelli2003 ER - TY - JOUR AU - More, S. H. AU - Breloer, M. AU - von Bonin, A. PY - 2001 DA - 2001// TI - Eukaryotic heat shock proteins as molecular links in innate and adaptive immune responses: Hsp60-mediated activation of cytotoxic T cells JO - Int Immunol VL - 13 UR - https://doi.org/10.1093/intimm/13.9.1121 DO - 10.1093/intimm/13.9.1121 ID - More2001 ER - TY - JOUR AU - Nowak, A. K. AU - Lake, R. A. AU - Bruce, W. S. AU - Robinson PY - 2006 DA - 2006// TI - Combined chemoimmunotherapy of solid tumours: Improving vaccines? JO - Advanced Drug Delivery Reviews VL - 58 UR - https://doi.org/10.1016/j.addr.2006.04.002 DO - 10.1016/j.addr.2006.04.002 ID - Nowak2006 ER - TY - JOUR AU - Berinstein, N. L. PY - 2007 DA - 2007// TI - Enhancing cancer vaccines with immunomodulators JO - Vaccine VL - 25s UR - https://doi.org/10.1016/j.vaccine.2007.06.043 DO - 10.1016/j.vaccine.2007.06.043 ID - Berinstein2007 ER -