Figure 5

Genes and proteins associated with angiogenesis were supressed by COX-2 gene knockdown. LV-COX-2siRNA-1 significantly inhibited the mRNA (A) and protein (C) expression of VEGFA, EGF, bFGF in SaOS2 cells. (B) VEGFA, VEGFB, VEGFC, EGF, bFGF protein expression in each group. Data are presented as mean ± s.e.m. * P < 0.01, # P < 0.001, compared with LV-Control and parental SaOS2 cell group.