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Table 2 p53 expression in relation to main tumor characteristics and treatment response

From: Evaluation of HER2 and p53 expression in predicting response to docetaxel-based first-line chemotherapy in advanced breast cancer

  p53 expression
  Total Low High p value
Age     
   < 55 yrs 18 13 5 n.s.
   ≥55 yrs 18 12 6  
ER expression     
   Negative 14 8 6 n.s.
   Positive 22 17 5  
PgR expression     
   Negative 13 9 4 n.s.
   Positive 23 16 7  
Grading #     
   G2 21 17 4 n.s.
   G3 15 8 7  
Stage    
   I-IIA 17 15 2 0.02
   IIB-III 16 7 9  
HER2     
   Negative" 27 21 6 n.s.
   Positive" 9 4 5  
Ki67     
   Negative 22 15 7 n.s.
   Positive 14 10 4  
Treatment response     
   CR+PR 15 11 4 n.s.
   SD+PD 21 14 7  
  1. n.s. = not significant; CR = complete response; PR = partial response; SD = stable disease; PD = disease progression. #According to Elston and Ellis classification (Ref. 31). *According to UICC-TNM classification of malignant tumours, sixth edition 2002 (Ref. 30). °At initial diagnosis time. "IHC 0,1+ and 2+ FISH negative were regarded as negative while IHC 3+ or 2+ FISH positive were regarded as positive.