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Table 2 p53 expression in relation to main tumor characteristics and treatment response

From: Evaluation of HER2 and p53 expression in predicting response to docetaxel-based first-line chemotherapy in advanced breast cancer

 

p53 expression

 

Total

Low

High

p value

Age

    

   < 55 yrs

18

13

5

n.s.

   ≥55 yrs

18

12

6

 

ER expression

    

   Negative

14

8

6

n.s.

   Positive

22

17

5

 

PgR expression

    

   Negative

13

9

4

n.s.

   Positive

23

16

7

 

Grading #

    

   G2

21

17

4

n.s.

   G3

15

8

7

 

Stage

    

   I-IIA

17

15

2

0.02

   IIB-III

16

7

9

 

HER2

    

   Negative"

27

21

6

n.s.

   Positive"

9

4

5

 

Ki67

    

   Negative

22

15

7

n.s.

   Positive

14

10

4

 

Treatment response

    

   CR+PR

15

11

4

n.s.

   SD+PD

21

14

7

 
  1. n.s. = not significant; CR = complete response; PR = partial response; SD = stable disease; PD = disease progression. #According to Elston and Ellis classification (Ref. 31). *According to UICC-TNM classification of malignant tumours, sixth edition 2002 (Ref. 30). °At initial diagnosis time. "IHC 0,1+ and 2+ FISH negative were regarded as negative while IHC 3+ or 2+ FISH positive were regarded as positive.