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Table 3 Grade 3-4 NCI-CTC toxicities in 104 enrolled patients

From: A multicenter prospective phase II randomized trial of epirubicin/vinorelbine versus pegylated liposomal doxorubicin/vinorelbine as first-line treatment in advanced breast cancer. A GOIM study

 

Arm A (EV = 54)

Arm B (PLD/V = 50)

 

No.

%

No.

%

Anemia

5

9.2

4

8

Neutropenia

10

18.5

11

22

Thrombocytopenia

1

1.8

-

-

Febrile neutropenia

3

5.5

1

2.0

Hepatotoxicity

2

3.7

2

4.0

Mucositis

4

7.4

6

12

PPE/skin

-

-

3

6

Alopecia

54

100

25

50

Neurologic

1

1.8

1

2.0

Cardiac

2

3.7

-

-

  1. Abbreviations: NCI-CTC: National Cancer Institute Common Toxicity Criteria; PPE: palmoplantar erithrodysthesia; EV: epirubicin/vinorelbine; PLD/V: pegylated liposomal doxorubicin/vinorelbine