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Table 3 Grade 3-4 NCI-CTC toxicities in 104 enrolled patients

From: A multicenter prospective phase II randomized trial of epirubicin/vinorelbine versus pegylated liposomal doxorubicin/vinorelbine as first-line treatment in advanced breast cancer. A GOIM study

  Arm A (EV = 54) Arm B (PLD/V = 50)
  No. % No. %
Anemia 5 9.2 4 8
Neutropenia 10 18.5 11 22
Thrombocytopenia 1 1.8 - -
Febrile neutropenia 3 5.5 1 2.0
Hepatotoxicity 2 3.7 2 4.0
Mucositis 4 7.4 6 12
PPE/skin - - 3 6
Alopecia 54 100 25 50
Neurologic 1 1.8 1 2.0
Cardiac 2 3.7 - -
  1. Abbreviations: NCI-CTC: National Cancer Institute Common Toxicity Criteria; PPE: palmoplantar erithrodysthesia; EV: epirubicin/vinorelbine; PLD/V: pegylated liposomal doxorubicin/vinorelbine