Schematic model of the role of UHRF1/DNMT1 complex in the regulation of p16INK4A and VEGF gene expressions. A. When the SRA domain of UHRF1 meets hemi-methylated DNA present in the p16INK4Apromoter, UHRF1 acts as a guide for DNMT1 to methylate the complementary DNA strand. Subsequently a p16INK4Agene repression and VEGF gene activation are maintained on the DNA daughter strands, i.e., in the daughter cancer cells. B. The UHRF1 down-regulation, by natural compounds such as TQ or polyphenols, induces the DNMT1 abundance decrease, that is accompanied by a p16INK4Agene re-expression and a down-regulation of VEGF gene expression.