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Figure 2 | Journal of Experimental & Clinical Cancer Research

Figure 2

From: Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties

Figure 2

Schematic model of the role of UHRF1/DNMT1 complex in the regulation of p16INK4A and VEGF gene expressions. A. When the SRA domain of UHRF1 meets hemi-methylated DNA present in the p16INK4Apromoter, UHRF1 acts as a guide for DNMT1 to methylate the complementary DNA strand. Subsequently a p16INK4Agene repression and VEGF gene activation are maintained on the DNA daughter strands, i.e., in the daughter cancer cells. B. The UHRF1 down-regulation, by natural compounds such as TQ or polyphenols, induces the DNMT1 abundance decrease, that is accompanied by a p16INK4Agene re-expression and a down-regulation of VEGF gene expression.

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