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Figure 2 | Journal of Experimental & Clinical Cancer Research

Figure 2

From: An imbalance in progenitor cell populations reflects tumour progression in breast cancer primary culture models

Figure 2

Ultrastructural and functional differences distinguish non-tumour from tumour primary cultures. A. TEM analysis of non-tumour cells revealed modest numbers of cytoplasmic vesicles (V nt ), single nuclei, distinct nuclear double membranes (NM nt ), regular mitochondria (M nt ) and well-organized RER (R nt ). Tumour cells showed abnormal peri-nuclear vesicles (V t ), >1 nucleus per cell with thin nuclear membranes (NM t ), abnormal mitochondria (M t ) and disorganized RER (R t ). B. Proliferation was enhanced in HG tumour cultures relative to LG tumour cultures or non-tumour cultures (left). Basal senescence, estimated by SA-β-galactosidase staining, was lower in tumour versus non-tumour cultures (right; p < 0.001).

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