Figure 4
Dynamic micro-MRA of the xenografts ( a 1-6 ) and hemodynamic of VM and angiogenesis in GBC-SD and SGC-996 xenografts ( b 1-6 ) in vivo. (A) The images were acquired before the injection of the contrast agents (HAS-Gd-DTPA, pre), 1, 3, 5, 10, and 15 min after injection. The tumor marginal area (red circle) of both GBC-SD and SGC-996 exhibited a signal that gradually increased in intensity. In the tumor center (yellow circle), GBC-SD exhibited spots in which the signal gradually increased in intensity (consistent with the intensity recorded for the tumor margin). However, the central region of SGC-996 maintained a lack of signal. (B) Hemodynamic of VM and angiogenesis in GBC-SD and SGC-996 nude mouse xenografts. All data are expressed as means ± SD. The time course of intensity of the tumor center (corresponding to the hemodynamic of VM) was consistent with the time course of intensity of tumor margin (corresponding to the hemodynamic of angiogenesis).