Figure 1

SULF1 SNP information, effects on age of disease onset, survival, and promoter activity. (A) The gene structure, SNP location, predicted functionality of SNPs, and electrophoresis gel pictures; (B) Haplotype combination of rs2623047 and rs6990375 and age of disease onset; G-G: rs2623047G-rs6990375G; G-A/A-G: rs2623047G-rs6990375A and rs2623047A-rs6990375G; A-A: rs2623047A-rs6990375A; (C) Progression-free survival; rs2623047 AA vs. rs2623047 GG/GA; (D) HeLa, OVCA429, and SKOV-3 cell lines were co-transfected with the rs2623047 G, or rs2623047 A constructor plasmid and Renilla-TK plasmids. The relative luciferase activity was assessed with the Renilla luciferase activity. Each experiment was performed in triplicate. * P < 0.05.