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Table 3 SULF1 Genotype distribution and age of disease onset

From: Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer

Genotypes Number of patients (%) Age at diagnosis
(years, mean ±SD) b
P- value
rs2623047 G>A a    0.027
   GG 16 (11.9) 56.8 ± 10.7  
   GA 80 (59.3) 61.2 ± 10.8  
   AA 39 (28.9) 65.0 ± 9.9  
   G allele frequency 112 (41.5)   P trend c = 0.007
   A allele frequency 158 (58.5)   
rs13264163 A>G    0.016
   AA 70 (51.4) 63.7 ± 10.5  
   AG 53 (39.0) 58.6 ± 10.5  
   GG 13 (9.6) 64.9 ± 10.6  
   A allele frequency 193 (71.0)   P trend c = 0.266
   G allele frequency 79 (29.0)   
rs6990375 G>A    0.013
   GG 58 (42.7) 60.0 ± 10.7  
   GA 63 (46.3) 61.8 ± 10.6  
   AA 15 (11.0) 69.1 ± 9.0  
   G allele frequency 179 (65.8)   P trend c = 0.009
   A allele frequency 93 (34.2)   
rs3802278 G>A    0.069
   GG 59 (43.4) 59.7 ± 11.4  
   GA 65 (47.8) 62.8 ± 10.0  
   AA 12 (8.8) 66.7 ± 9.5  
   G allele frequency 183 (67.3)   P trend c = 0.021
   A allele frequency 89 (32.7)   
rs3087714 C>T    0.119
   CC 63 (46.3) 60.1 ± 11.3  
   CT 62 (45.6) 62.7 ± 10.1  
   TT 11 (8.1) 66.6 ± 10.0  
   C allele frequency 188 (69.1)   P trend c = 0.041
   T allele frequency 84 (30.9)   
  1. a One sample failed in this genotype
  2. b One-way ANOVA (Analysis of variance) for age differences among 3 genotypes for each SNP
  3. c P values for the trend test of age at diagnosis among 3 genotypes for each SNP from a general
  4. linear model