Table 3 SULF1 Genotype distribution and age of disease onset

rs2623047 G>A ^a

0.027

   GG

16 (11.9)

56.8 ± 10.7

   GA

80 (59.3)

61.2 ± 10.8

   AA

39 (28.9)

65.0 ± 9.9

   G allele frequency

112 (41.5)

P _trend ^c = 0.007

   A allele frequency

158 (58.5)

rs13264163 A>G

0.016

   AA

70 (51.4)

63.7 ± 10.5

   AG

53 (39.0)

58.6 ± 10.5

   GG

13 (9.6)

64.9 ± 10.6

   A allele frequency

193 (71.0)

P _trend ^c = 0.266

   G allele frequency

79 (29.0)

rs6990375 G>A

0.013

   GG

58 (42.7)

60.0 ± 10.7

   GA

63 (46.3)

61.8 ± 10.6

   AA

15 (11.0)

69.1 ± 9.0

   G allele frequency

179 (65.8)

P _trend ^c = 0.009

   A allele frequency

93 (34.2)

rs3802278 G>A

0.069

   GG

59 (43.4)

59.7 ± 11.4

   GA

65 (47.8)

62.8 ± 10.0

   AA

12 (8.8)

66.7 ± 9.5

   G allele frequency

183 (67.3)

P _trend ^c = 0.021

   A allele frequency

89 (32.7)

rs3087714 C>T

0.119

   CC

63 (46.3)

60.1 ± 11.3

   CT

62 (45.6)

62.7 ± 10.1

   TT

11 (8.1)

66.6 ± 10.0

   C allele frequency

188 (69.1)

P _trend ^c = 0.041

   T allele frequency

84 (30.9)