Table 3 SULF1 Genotype distribution and age of disease onset
| Genotypes | Number of patients (%) |
Age at diagnosis (years, mean ±SD) b | P- value |
|---|---|---|---|
| rs2623047 G>A a | 0.027 | ||
| GG | 16 (11.9) | 56.8 ± 10.7 | |
| GA | 80 (59.3) | 61.2 ± 10.8 | |
| AA | 39 (28.9) | 65.0 ± 9.9 | |
| G allele frequency | 112 (41.5) | P trend c = 0.007 | |
| A allele frequency | 158 (58.5) | ||
| rs13264163 A>G | 0.016 | ||
| AA | 70 (51.4) | 63.7 ± 10.5 | |
| AG | 53 (39.0) | 58.6 ± 10.5 | |
| GG | 13 (9.6) | 64.9 ± 10.6 | |
| A allele frequency | 193 (71.0) | P trend c = 0.266 | |
| G allele frequency | 79 (29.0) | ||
| rs6990375 G>A | 0.013 | ||
| GG | 58 (42.7) | 60.0 ± 10.7 | |
| GA | 63 (46.3) | 61.8 ± 10.6 | |
| AA | 15 (11.0) | 69.1 ± 9.0 | |
| G allele frequency | 179 (65.8) | P trend c = 0.009 | |
| A allele frequency | 93 (34.2) | ||
| rs3802278 G>A | 0.069 | ||
| GG | 59 (43.4) | 59.7 ± 11.4 | |
| GA | 65 (47.8) | 62.8 ± 10.0 | |
| AA | 12 (8.8) | 66.7 ± 9.5 | |
| G allele frequency | 183 (67.3) | P trend c = 0.021 | |
| A allele frequency | 89 (32.7) | ||
| rs3087714 C>T | 0.119 | ||
| CC | 63 (46.3) | 60.1 ± 11.3 | |
| CT | 62 (45.6) | 62.7 ± 10.1 | |
| TT | 11 (8.1) | 66.6 ± 10.0 | |
| C allele frequency | 188 (69.1) | P trend c = 0.041 | |
| T allele frequency | 84 (30.9) |