COX-2 mediated VEGF up-regulation in NSCLC cells was changed with treatment with several reagents. VEGF expression after treatment with several reagents was showed in A549 (A), H460 (B), and A431 cells (C). Red curve indicated cells treatment with COX-2, black curve indicated with COX-2 and AH6809, green curve indicated with COX-2 and KT5720, and blue curve indicated with COX-2 and RO-31-8425. Comparison of G-mean fluorescence intensity of VEGF was showed (D). G-mean, geometric mean.