Figure 3

Anti-c-Met/PE38KDEL induced inhibition of protein synthesis. The ability of IT to inhibit protein synthesis in GES-1, MKN-45 and SGC7901 cells were evaluated by using the [³H]-leucine incorporation assay. [³H]-leucine incorporation for protein synthesis as a function of varying concentration of IT (expressed as a percentage of untreated cells), Normal cell GES-1 (A), GC cells MKN-45 (B) and SGC7901 (C) were treated with varying concentration of IT for 24 hr and 48 hr.