Figure 4
From: Application of Benchtop-magnetic resonance imaging in a nude mouse tumor model
Monitoring of xenograft tumor growth. (A): Transaxial NMR images of a mouse (face-down position) bearing two s.c. xenografts (left: 1411HP germ cell tumor, right: DLD-1 colon carcinoma) analysed over 5 weeks (d13, d20, d27, d34 post cell injection). Depicted images were taken 10 min after i.v. application of Gd-BOPTA. White arrows point at tumors. (B): Following tumor growth of example shown in Figure 4A as analysed by calliper measurements and volume calculation compared to analyses by pixel extension of tumor sections based on NMR images (with or without Gd-BOPTA (CA)). Both tumor volume (V) and tumor section extent (A) comparably increased over the observation period. (C): Correlation of both methods: calculation of tumor growth by calliper measurement (V) and pixel extension analyses based on NMR images (A) of all 12 tumors.