Figure 1From: Reduced expression of SMAD4 in gliomas correlates with progression and survival of patientsImmunohistochemical staining of SMAD4 protein in tumor cells of GBM (A) and astrocytoma (B) (Original magnification ×400). Staining for this antigen is described in Materials and Methods. Positive staining of SMAD4 is seen in the cytoplasm and/or nuclei of tumors cells and is more abundant in the low- (B) than the high-grade (A) tumors. Intensively positive expression of SMAD4 (C) was observed in normal brain tissues.Back to article page