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Table 2 Quantification of vessel area and the number of vessel branches around the transplantation tumor

From: HIF-1α effects on angiogenic potential in human small cell lung carcinoma

 

day 8

day 11

day 14

day 17

Vessel length (pixels)

    

Control (n = 10 × 4)

2106 ± 143

1967 ± 113

1457 ± 135

2183 ± 156

NCI/H446(n = 10 × 4)

2452 ± 117

2564 ± 96*

2687 ± 103*

2798 ± 135*

NCI/H446/HIF-1α(n = 15 × 4)

2742 ± 83

2814 ± 154

2910 ± 137§

2994 ± 124§

NCI/H446/siHIF-1α(n = 12 × 4)

2331 ± 53#

2268 ± 106#

2236 ± 162#

2203 ± 116#

Vessel Branch points

    

Control (n = 10 × 4)

76 ± 5

82 ± 9

73 ± 8

89 ± 5

NCI/H446(n = 10 × 4)

92 ± 7

101 ± 11

105 ± 6*

117 ± 7*

NCI/H446/HIF-1α(n = 15 × 4)

116 ± 16

123 ± 11§

128 ± 9§

134 ± 21§

NCI/H446/siHIF-1α(n = 12 × 4)

82 ± 5#

87 ± 6#

92 ± 11#

102 ± 13#

  1. The MIQAS quantified system was used for the quantification of the two vessel parameters around the transplantation tumor in the CAM. Data are presented as means ± SD.
  2. *Significant difference from group controls at p < 0.05 by use of paired sample t-test
  3. §Significant difference from group controls at p < 0.05 by use of one-way ANOVA
  4. #significant difference from group controls at p < 0.05 by use of one-way ANOVA