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Table 3 The effect of HIF-1α on angiogenic gene expression

From: HIF-1α effects on angiogenic potential in human small cell lung carcinoma

UniGeneID

Gene name

Gene Symbol

Fold change

(ratio ≥ 2, p < 0.05)

   

A

B

Hs.143250

Tenascin C (hexabrachion)

TNC

5.28

-3.23

Hs.654458

Interleukin 6 (interferon, beta 2)

IL6

5.29

-2.27

Hs.73793

Vascular endothelial growth factorA

VEGF-A

6.76

-3.98

Hs.437322

Tumor necrosis factor, alpha-induced protein 6

TNFAIP6

6.96

-4.75

Hs.570855

Platelet derived growth factor C

PDGFC

2.26

-3.21

Hs.701982

Interleukin 1 receptor, type I

IL1R1

2.64

-2.21

Hs.203717

Fibronectin 1

FN1

2.31

-2.57

Hs.567641

Myocardin

MYOCD

3.03

-2.08

Hs.517581

Heme oxygenase (decycling) 1

HMOX1

2.64

-2.73

Hs.687274

Matrix metallopeptidase 28

MMP28

4.39

-3.67

Hs.2399

Matrix metallopeptidase 14

MMP14

2.97

-2.24

Hs.473721

Glucose transporter 1

GLUT1

2.98

-2.16

Hs.167584

Glucose transporter 2

GLUT2

3.74

-2.05

Hs.485572

Suppressor of cytokine signaling 2

SOCS2

-6.06

3.06

Hs.450230

Insulin-like growth factor binding protein 3

IGFBP3

-4.02

2.17

Hs.653377

Insulin-like growth factor 1 receptor

IGF1R

-2.00

2.89

Hs. 8867

Cysteine-rich, angiogenic inducer, 61

CYR61

-3.03

2.18

  1. cDNA microarray analysis was used to screen angiogenic genes with differential expression (more than 2.0-fold) between the following two comparison groups: Ad5 vs. Ad5-HIF-1α and Ad5 vs. Ad5-siHIF-1α.
  2. A = Ad5 vs. Ad5-HIF-1α; 11 genes were upregulated and 4 genes were downregulated by HIF-1α
  3. B = Ad5 vs. Ad5-siHIF-1α; 4 genes were upregulated and 11 genes were downregulated by siHIF-1α (contrasting the A group)