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Figure 2 | Journal of Experimental & Clinical Cancer Research

Figure 2

From: Response to dexamethasone is glucose-sensitive in multiple myeloma cell lines

Figure 2

Hyperglycemia and dexamethasone (DEX) do not have an additive effect on TXNIP-ROS-TRX. Cells were grown in 20 mM glucose (GLC) ± dexamethasone (25 μM) (DEX) for 24 h. Data is represented as fold change over 20 mM baseline, with > 1 fold change indicating an increase over baseline and < 1 a decrease over baseline levels. Multiple myeloma-derived ARH77, NCIH929 and U266B1, which showed dex response, were grouped and the mean value ± SD for the group presented above. A. Thioredoxin-interacting protein (TXNIP) RNA levels. B. Reactive oxygen species (ROS)-levels. C.Thioredoxin (TRX) activity. Black star represents p-value compared to 20 mM GLC alone, cross indicates p- value of MC/CAR compared to grouped value.

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