A. Blocking glucose transport blocks the hyperglycemia effect oon thioredoxin-interacting protein (TXNIP) RNA levels. Cells were grown in 5 mM glucose or 20 mM chronically.. For glucose uptake inhibition, phlor (200 μM) was added to 20 mM media and cells harvested after 24 hours. Fold change is based on comparison to 5 mM glucose. B. Reactive oxygen species (ROS)-levels in response to phlor pre-treatment. Cells were treated as in A. ROS levels were measured as mean fluorescence of 50,000 cells and compared to 5 mM as baseline.