Figure 2

Association of NF-κB and Notch1 expression with lymphangiogenesis in ESCC. (A) NF-κB expression in ESCC tissue was positively correlated with LVD in tumors. (B) Notch1 expression in ESCC tissue was negatively correlated with LVD in tumors. (C) The mean histoscore of LVD expression was higher in ESCC tissue with high levels of NF-κB expression (5.95 ± 0.35) than in those with low levels of NF-κB expression (4.22 ± 0.39; P < 0.05). Conversely, the mean LVD histoscore (VEGFR-3 expression) was lower in ESCC tissue with high levels of Notch1 expression (3.92 ± 0.38) than in those with low levels of Notch1 expression (6.20 ± 0.31; P < 0.05).