Figure 3

Association of NF-κB and Notch1 expression with VEGF-C in ESCC. (A) NF-κB expression in ESCC tissue was positively correlated with VEGF-C expression in tumors. (B) Notch1 expression in ESCC tissue was negatively correlated with VEGF-C expression in tumors. (C) The mean histoscore of VEGF-C expression was higher in ESCC tissue with high levels of NF-κB expression (6.48 ± 0.44) than in those with low levels of NF-κB expression (3.53 ± 0.39; P < 0.05). Conversely, the mean histoscore of VEGF-C expression was lower in ESCC tissue with high levels of Notch1 expression (3.41 ± 0.37) than in those with low levels of Notch1 expression (6.51 ± 0.84; P < 0.05).