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Table 1 Conditions involving apoptosis

From: Apoptosis in cancer: from pathogenesis to treatment

Physiological conditions
Programmed cell destruction in embryonic development for the purpose of sculpting of tissue
Physiologic involution such as shedding of the endometrium, regression of the lactating breast
Normal destruction of cells accompanied by replacement proliferation such as in the gut epithelium
Involution of the thymus in early age
Pathological conditions
Anticancer drug induced cell death in tumours
Cytotoxic T cell induced cell death such as in immune rejection and graft versus host disease
Progressive cell death and depletion of CD4+ cells in AIDs
Some forms of virus-induced cell death, such as hepatitis B or C
Pathologic atrophy of organs and tissues as a result of stimuli removal e.g. prostatic atrophy after orchidectomy
Cell death due to injurious agents like radiation, hypoxia and mild thermal injury
Cell death in degenerative diseases such as Alzheimer's disease and Parkinson's disease
Cell death that occurs in heart diseases such as myocardial infarction