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Physiological conditions
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Programmed cell destruction in embryonic development for the purpose of sculpting of tissue
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Physiologic involution such as shedding of the endometrium, regression of the lactating breast
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Normal destruction of cells accompanied by replacement proliferation such as in the gut epithelium
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Involution of the thymus in early age
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Pathological conditions
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Anticancer drug induced cell death in tumours
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Cytotoxic T cell induced cell death such as in immune rejection and graft versus host disease
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Progressive cell death and depletion of CD4+ cells in AIDs
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Some forms of virus-induced cell death, such as hepatitis B or C
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Pathologic atrophy of organs and tissues as a result of stimuli removal e.g. prostatic atrophy after orchidectomy
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Cell death due to injurious agents like radiation, hypoxia and mild thermal injury
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Cell death in degenerative diseases such as Alzheimer's disease and Parkinson's disease
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Cell death that occurs in heart diseases such as myocardial infarction
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