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Figure 5 | Journal of Experimental & Clinical Cancer Research

Figure 5

From: The expression and role of protein kinase C (PKC) epsilon in clear cell renal cell carcinoma

Figure 5

Changes of caspase-3 activity in 769P cells after PKCε downregulated and cytotoxic drug treatment. 769P cells were transfected with PKCε siRNA; untransfected cells were used as blank control. At 72 h after siRNA transfection, cells were treated with indicated doses of sunitinib or 5-fluorouracil. Panel A shows that the caspase-3 activity was significantly higher in PKCε siRNA-transfected cells, either with or without drug treatment, than in untransfected cells (P < 0.01) and was higher in the cells underwent both siRNA transfection and drug treatment than in those underwent only siRNA transfection (P < 0.05). Panel B shows that the caspase-3 activity was significantly higher in the cells underwent both siRNA transfection and drug treatment than in those underwent only drug treatment (P < 0.05).

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