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Table 2 Plasma concentrations of 5-fluorouracil (μg/mL) during a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in 49 Japanese patients with esophageal squamous cell carcinoma

From: Effects of plasma concentrations of 5-fluorouracil on long-term survival after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma

Group

Total

Survival of 5 years or more

Survival of less than 5 years

P a)

N

49

21

28

 

1st cycle/1st course

Day 3, PM 5:00

0.109 ± 0.060

0.122 ± 0.080

0.100 ± 0.041

0.294

 

Day 4, AM 5:00

0.076 ± 0.040

0.088 ± 0.044

0.068 ± 0.036

0.097

2nd cycle/1st course

Day 10, PM 5:00

0.150 ± 0.074

0.137 ± 0.071

0.158 ± 0.077

0.357

 

Day 11, AM 5:00

0.134 ± 0.047

0.132 ± 0.048

0.136 ± 0.047

0.798

1st cycle/2nd course

Day 38, PM 5:00

0.102 ± 0.056

0.097 ± 0.067

0.105 ± 0.049

0.676

 

Day 39, AM 5:00

0.076 ± 0.041

0.077 ± 0.042

0.076 ± 0.042

0.897

2nd cycle/2nd course

Day 45, PM 5:00

0.146 ± 0.080

0.158 ± 0.101

0.136 ± 0.059

0.364

 

Day 46, AM 5:00

0.119 ± 0.047

0.126 ± 0.036

0.114 ± 0.054

0.399

Average of 8 sampling points

0.114 ± 0.034

0.118 ± 0.036

0.112 ± 0.032

0.536

  1. a) Survival of 5 years or more vs. less than 5 years.