HGF/c-Met related activation of β-catenin in hepatoblastoma

Table 1 Histologic type and subtype, β-catenin and Y654 β-catenin IHC and CTNNB1 gene status of hepatoblastomas with mutations.

Case Number	Histologic Type	Histologic Subtype	β-catenin	Y654-β-catenin	*CTNNB1* mutation
CCRG9	Epithelial	Pure fetal	dc	cytoplasmic	32D > Y
CCRG15	Epithelial	Fetal/embryonal	dn	negative	33S > C
CCRG16	Mixed	Fetal/embryonal	dc+dn	cytoplasmic	32D > Y
CCRG48	Epithelial	Pure fetal	dc	cytoplasmic	37S > Y
CCRG61	Epithelial	Pure fetal	dc	cytoplasmic	34G > V
CCRG63	Epithelial	Fetal/embryonal	dn	nuclear	32D > N
CCRG64^a	Epithelial	Fetal/embryonal	dc+fn	negative	32D > V
CCRG64^b	Epithelial	Pure fetal	fn	negative	32D > V
CCRG65	Epithelial	Pure fetal	dn	negative	34G > R
CCRG68	Mixed	Fetal/embryonal	dc	cytoplasmic	34G > E
CCRG70	Epithelial	Pure fetal	dc+fn	cytoplasmic	32D > V
CCRG79	Epithelial	Fetal/embryonal	dc+fn	cytoplasmic	32D > N
CCRG82	Mixed	Pure fetal	fc+fn	cytoplasmic	33S > P
CCRG87	Mixed	Pure fetal	dc+dn	cytoplasmic	35I > S
CCRG88	Mixed	Fetal/embryonal	dc+dn	cytoplasmic	32D > V

^a Diagnostic specimen from sample CCRG64. ^b Post-chemotherapy specimen from sample CCRG64. Abbreviations: dc, diffuse cytoplasmic; dn, diffuse nuclear; fc, focal cytoplasmic; fn, focal nuclear

ISSN: 1756-9966