Clinicopathological significance of non-small cell lung cancer with high prevalence of Oct-4 tumor cells

Table 1 Association of Oct-4 Expression with clinical features in NSCLC

Features	Total	Oct-4 expression n(%)^a		P	χ ²
		Negative	Positive
Gender				0.330	0.674
Male	82	42 (51.2)	40 (48.8)
Female	31	14 (45.2)	17 (54.8)
Age (yr)^b				0.348	1.082
≤58	54	24 (44.4)	30 (55.6)
> 58	59	32 (54.2)	27 (45.8)
Smoking				0.849	0.072
Yes	45	23 (51.1)	22 (48.9)
No	68	33 (48.5)	35 (51.5)
Histological type				< 0.001	13.637
Adenocarcinoma	58	21 (36.2)	37 (63.8)
Squamous cell carcinoma	52	35 (67.3)	17 (32.7)
Large cell carcinoma	3	0 (0.0)	3 (100.0)
Histological differentiation				0.001	32.463
Well differentiated^c	27	24 (88.9)	3 (11.1)
Moderately differentiated	34	20 (58.8)	14 (41.2)
Poorly differentiated^d	52	12 (23.1)	40 (76.9)
Adenocarcinoma				0.001	17.324
Well differentiated^c	15	12 (80.0)	3 (20.0)
Moderately differentiated	14	4 (28.6)	10 (71.4)
Poorly differentiated	29	5 (17.2)	24 (82.8)
Squamous cell carcinoma				0.001	16.780
Well differentiated	12	12 (100.0)	0 (0.0)
Moderately differentiated	20	16 (80.0)	4 (20.0)
Poorly differentiated	20	7 (35.0)	13 (65.0)
Local advance				0.205	3.172
T₁	30	17 (56.7)	13 (43.3)
T₂	48	26 (54.2)	22 (45.8)
T₃/T₄	35	13 (37.1)	22 (62.9)
Lymph node metastasis				0.466	1.529
N₀	46	22 (47.8)	24 (52.2)
N₁	23	14 (60.9)	9 (39.1)
N₂	44	20 (45.5)	24 (54.5)
Clinical stage				0.680	0.227
I/II	81	39 (48.1)	42 (51.9)
III/IV	32	17 (53.1)	15 (46.9)
MVD expression^a				0.348	1.082
Positive	59	32 (54.2)	27 (45.8)
Negative	54	24 (44.4)	30 (55.6)
VEGF expression^a				0.574	0.435
Positive	57	30 (52.6)	27 (47.4)
Negative	56	26 (46.4)	30 (53.6)
Ki-67 expression^a				0.001	16.430
Positive	54	16 (29.6)	38 (70.4)
Negative	59	40 (67.8)	19 (32.2)

^aPatients were divided according to the median values of immunohistochemical histoscores
^bPatients were divided according to median age
^cBronchioloalveolar carcinoma was included in well differentiated
^dLarge cell carcinoma was included in poorly differentiated

ISSN: 1756-9966