|
Variables
|
Univariate
|
Multivariate
|
|---|
| |
HR
|
95%CI
|
P
|
HR
|
95%CI
|
P
|
|---|
|
Age
|
0.988
|
0.969-1.008
|
0.231
|
1.001
|
0.978-1.025
|
0.922
|
|
Gender
|
0.852
|
0.517-1.405
|
0.530
|
0.525
|
0.305-0.906
|
0.121
|
|
Smoking
|
1.179
|
0.740-1.880
|
0.489
|
1.277
|
0.743-2.195
|
0.376
|
|
Histological type
|
1.087
|
0.697-1.695
|
0.713
|
1.168
|
0.706-1.932
|
0.546
|
|
Histological differentiation
|
3.727
|
2.139-6.495
|
< 0.001
|
3.666
|
1.937-6.939
|
0.001
|
|
Local advance
|
1.282
|
0.920-1.731
|
0.149
|
1.222
|
0.928-1.609
|
0.153
|
|
Lymph node metastasis
|
1.487
|
1.148-1.927
|
0.003
|
1.042
|
0.743-1.461
|
0.813
|
|
Oct-4 expression
|
1.105
|
1.007-1.024
|
< 0.001
|
1.011
|
1.003-1.020
|
0.009
|
|
Age
|
0.990
|
0.963-1.018
|
0.482
|
1.014
|
0.978-1.051
|
0.450
|
|
Gender
|
0.786
|
0.408-1.512
|
0.470
|
0.296
|
0.087-1.008
|
0.052
|
|
Smoking
|
1.231
|
0.646-2.346
|
0.527
|
0.733
|
0.237-2.265
|
0.590
|
|
Histological type
|
0.785
|
0.408-1.512
|
0.470
|
0.869
|
0.386-1.956
|
0.735
|
|
Histological differentiation
|
1.428
|
0.701-2.910
|
0.327
|
1.418
|
0.591-3.405
|
0.434
|
|
Local advance
|
1.191
|
0.780-1.817
|
0.418
|
0.934
|
0.560-1.558
|
0.793
|
|
Lymph node metastasis
|
1.217
|
0.833-1.778
|
0.310
|
1.560
|
0.976-2.495
|
0.063
|
|
Oct-4 expression
|
1.014
|
1.002-1.025
|
0.021
|
1.024
|
1.007-1.042
|
0.005
|
|
Age
|
0.994
|
0.965-1.024
|
0.688
|
1.005
|
0.967-1.044
|
0.801
|
|
Gender
|
0.790
|
0.395-1.580
|
0.505
|
0.401
|
0.166-0.966
|
0.096
|
|
Smoking
|
1.232
|
0.635-2.389
|
0.537
|
0.921
|
0.382-2.219
|
0.855
|
|
Histological type
|
1.439
|
0.767-2.700
|
0.257
|
1.247
|
0.598-2.600
|
0.556
|
|
Histological differentiation
|
1.925
|
0.934-3.969
|
0.076
|
1.962
|
0.791-4.868
|
0.146
|
|
Local advance
|
1.313
|
0.822-2.099
|
0.254
|
1.231
|
0.743-2.042
|
0.420
|
|
Lymph node metastasis
|
1.415
|
0.953-2.103
|
0.086
|
1.472
|
0.933-2.323
|
0.097
|
|
Oct-4 expression
|
1.010
|
0.999-1.022
|
0.018
|
1.011
|
0.998-1.024
|
0.042
|
- Variable 1, Oct-4 expression was an independent prognostic factor, adjusted by histological differentiation, in all cases
- Variable 2, Oct-4 expression was an independent factor in MVD-negative cases
- Variable 3, Oct-4 expression was an independent factor in VEGF-negative cases
- Abbreviations: HR, hazard ratio; CI, confidence interval
