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Table 2 Genetic instability between primary and metastatic tumor at Case #13

From: Array-based comparative genomic hybridization for genomic-wide screening of DNA copy number alterations in aggressive bone tumors

 

location

Gene name

metastasis (≧1.30)

primary tumor

m/p ratio

1p

1p36

CDC2L1(p58)

1.39

1.33

1.05

1p36.33

PPKCZ

1.52

1.24

1.23

1p36.33

TP73

1.48

1.58

0.94

1p36.31

D1S214

1.76

1.21

1.45*

1p36.22

D1S1635

1.88

1.33

1.41*

1p36.13

D1S199

1.51

1.22

1.24

1q

1q21

WI-5663

1.73

1.64

1.05

5p

5p13

DAB2

1.87

1.55

1.21

8q

8q24.11-q24

EXT1

1.44

1.03

1.40*

8q24-qter

PTK2

1.51

1.31

1.15

8q tel

SHGC-3110

1.40

1.29

1.09

8q tel

U11829

1.35

1.16

1.16

9p

9p11.2

AFM137XA11

1.52

1.16

1.31*

12p

12p tel

8 M16/SP6

1.49

1.08

1.38*

12p tel

SHGC-5557

1.52

1.34

1.13

12p13

CCND2

1.71

1.29

1.33*

12p13.1-p12

CDLN1B(p27)

1.53

1.25

1.22

14q

14q32.32

AKT1

1.68

1.51

1.11

14q tel

IGH(D14S308)

1.51

1.16

1.30*

14q tel

IGH(SHGC-36156)

1.39

1.14

1.22

17p

17p tel

282 M15/SP6

1.52

1.14

1.33*

17p13.3

HIC1

1.42

1.04

1.37*

17p13.1

TP53(p53)

1.40

1.19

1.18

17p12-17p11.2

LLGL1

1.67

2.06

0.81*

17p12-17p11.2

FLI, TOP3A

1.60

1.88

0.85*

18q

18q11.2

LAMA3

1.73

0.87

1.99*

20q

20q13.1-q13.2

PTPN1

1.46

1.43

1.02

20q13

TNFRSF6B(DCR3)

1.50

1.23

1.22

21q

21q22.3

RUNX1(AML1)

1.40

1.16

1.21

21q22

DYRK1A

1.37

1.13

1.21

 

21q tel

PCNT2(KEN)

1.56

1.30

1.20

  1. *m/p ratio: the ratio of DCNAs between the primary (p) and metastatic (m) tumor (≧1.30 or ≦0.85). No DCNAs of the loss (≦0.85) was detected in the metastasis.
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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