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Table 2 Genetic instability between primary and metastatic tumor at Case #13

From: Array-based comparative genomic hybridization for genomic-wide screening of DNA copy number alterations in aggressive bone tumors

  location Gene name metastasis (1.30) primary tumor m/p ratio
1p 1p36 CDC2L1(p58) 1.39 1.33 1.05
1p36.33 PPKCZ 1.52 1.24 1.23
1p36.33 TP73 1.48 1.58 0.94
1p36.31 D1S214 1.76 1.21 1.45*
1p36.22 D1S1635 1.88 1.33 1.41*
1p36.13 D1S199 1.51 1.22 1.24
1q 1q21 WI-5663 1.73 1.64 1.05
5p 5p13 DAB2 1.87 1.55 1.21
8q 8q24.11-q24 EXT1 1.44 1.03 1.40*
8q24-qter PTK2 1.51 1.31 1.15
8q tel SHGC-3110 1.40 1.29 1.09
8q tel U11829 1.35 1.16 1.16
9p 9p11.2 AFM137XA11 1.52 1.16 1.31*
12p 12p tel 8 M16/SP6 1.49 1.08 1.38*
12p tel SHGC-5557 1.52 1.34 1.13
12p13 CCND2 1.71 1.29 1.33*
12p13.1-p12 CDLN1B(p27) 1.53 1.25 1.22
14q 14q32.32 AKT1 1.68 1.51 1.11
14q tel IGH(D14S308) 1.51 1.16 1.30*
14q tel IGH(SHGC-36156) 1.39 1.14 1.22
17p 17p tel 282 M15/SP6 1.52 1.14 1.33*
17p13.3 HIC1 1.42 1.04 1.37*
17p13.1 TP53(p53) 1.40 1.19 1.18
17p12-17p11.2 LLGL1 1.67 2.06 0.81*
17p12-17p11.2 FLI, TOP3A 1.60 1.88 0.85*
18q 18q11.2 LAMA3 1.73 0.87 1.99*
20q 20q13.1-q13.2 PTPN1 1.46 1.43 1.02
20q13 TNFRSF6B(DCR3) 1.50 1.23 1.22
21q 21q22.3 RUNX1(AML1) 1.40 1.16 1.21
21q22 DYRK1A 1.37 1.13 1.21
  21q tel PCNT2(KEN) 1.56 1.30 1.20
  1. *m/p ratio: the ratio of DCNAs between the primary (p) and metastatic (m) tumor (1.30 or 0.85). No DCNAs of the loss (0.85) was detected in the metastasis.