Figure 5
From: ABT-737 reverses the acquired radioresistance of breast cancer cells by targeting Bcl-2 and Bcl-xL
ABT-737 increases the radiation-induced apoptosis of MDA-MB-231R cells. (A) The proportion of Annexin V-positive and propidium iodide-negative cells (apoptotic cells) was significantly higher in the ABT-737-treated group compared to the untreated and DMSO control groups. (B) A caspase-3 colorimetric assay was performed to confirm our findings. The activity of caspase 3 was significantly upregulated after treatment with ABT-737. Columns, mean of three independent experiments; bars, SD.