Figure 1
From: FGFR-1 amplification in metastatic lymph-nodal and haematogenous lobular breast carcinoma
Metastatic lobular breast carcinoma to the colon (A, H&E), to the lymph-node (B, H&E) and to the bone (C, GATA-3 immunoexpression); FISH analysis showing absence of Her-2/neu (D) and topoisomerase-IIĪ± (E) gene amplification, avoiding selection of the patients to targeted and individualized chemiotherapies. FGFR-1 gene amplification in a metastasis of lobular breast carcinoma by CISH analysis (F).