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Table 1 Metastatic lobular breast carcinoma with matched primary tumours: FGFR1 gene status by molecular analysis

From: FGFR-1 amplification in metastatic lymph-nodal and haematogenous lobular breast carcinoma

FGFR-1 gene status by chromogenic in situ hybridization (CISH) FISH analysis Immunophenotyping
Topoisomerase-IIα Her-2/neu
Primary breast carcinoma Tissue metastases Both primary and metastases HER2 ER PR Ki67%
1 infiltrative lobular breast carcinoma amplified lymph-nodal amplified not-amplified not-amplified 0 positive positive high
2 infiltrative lobular breast carcinoma amplified lymph-nodal amplified not-amplified not-amplified 0 positive positive low
3 infiltrative lobular breast carcinoma amplified haematogenous amplified not-amplified amplified (in mts) 1+ positive positive low
4 infiltrative lobular breast carcinoma gains lymph-nodal gains not-amplified not-amplified 0 positive positive low
5 infiltrative lobular breast carcinoma gains lymph-nodal gains not-amplified not-amplified 0 positive positive medium
6 infiltrative lobular breast carcinoma gains lymph-nodal gains not-amplified not-amplified 0 positive positive low
7 infiltrative lobular breast carcinoma gains lymph-nodal gains not-amplified not-amplified 0 positive positive low
8 infiltrative lobular breast carcinoma gains lymph-nodal gains not-amplified not-amplified 0 positive positive low
9 infiltrative lobular breast carcinoma gains lymph-nodal gains not-amplified not-amplified 0 positive positive low
10 infiltrative lobular breast carcinoma disomic lymph-nodal gains not-amplified not-amplified 0 positive positive low
11 infiltrative lobular breast carcinoma disomic lymph-nodal gains not-amplified not-amplified 0 positive positive low
12 infiltrative lobular breast carcinoma disomic lymph-nodal gains not-amplified not-amplified 0 positive positive low
13 infiltrative lobular breast carcinoma disomic haematogenous gains not-amplified not-amplified 0 positive positive low
14 infiltrative lobular breast carcinoma disomic haematogenous disomic not-amplified not-amplified 0 positive positive low
15 infiltrative lobular breast carcinoma disomic haematogenous disomic not-amplified not-amplified 0 positive positive low
  1. Amplified: >6 or cluster of signals; gains: 3–5 signals.
  2. ER: estrogen receptor, PR: progesteron receptor.