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Table 1 Metastatic lobular breast carcinoma with matched primary tumours: FGFR1 gene status by molecular analysis

From: FGFR-1 amplification in metastatic lymph-nodal and haematogenous lobular breast carcinoma

FGFR-1 gene status by chromogenic in situ hybridization (CISH)

FISH analysis

Immunophenotyping

Topoisomerase-IIĪ±

Her-2/neu

Primary breast carcinoma

Tissue metastases

Both primary and metastases

HER2

ER

PR

Ki67%

1

infiltrative lobular breast carcinoma

amplified

lymph-nodal

amplified

not-amplified

not-amplified

0

positive

positive

high

2

infiltrative lobular breast carcinoma

amplified

lymph-nodal

amplified

not-amplified

not-amplified

0

positive

positive

low

3

infiltrative lobular breast carcinoma

amplified

haematogenous

amplified

not-amplified

amplified (in mts)

1+

positive

positive

low

4

infiltrative lobular breast carcinoma

gains

lymph-nodal

gains

not-amplified

not-amplified

0

positive

positive

low

5

infiltrative lobular breast carcinoma

gains

lymph-nodal

gains

not-amplified

not-amplified

0

positive

positive

medium

6

infiltrative lobular breast carcinoma

gains

lymph-nodal

gains

not-amplified

not-amplified

0

positive

positive

low

7

infiltrative lobular breast carcinoma

gains

lymph-nodal

gains

not-amplified

not-amplified

0

positive

positive

low

8

infiltrative lobular breast carcinoma

gains

lymph-nodal

gains

not-amplified

not-amplified

0

positive

positive

low

9

infiltrative lobular breast carcinoma

gains

lymph-nodal

gains

not-amplified

not-amplified

0

positive

positive

low

10

infiltrative lobular breast carcinoma

disomic

lymph-nodal

gains

not-amplified

not-amplified

0

positive

positive

low

11

infiltrative lobular breast carcinoma

disomic

lymph-nodal

gains

not-amplified

not-amplified

0

positive

positive

low

12

infiltrative lobular breast carcinoma

disomic

lymph-nodal

gains

not-amplified

not-amplified

0

positive

positive

low

13

infiltrative lobular breast carcinoma

disomic

haematogenous

gains

not-amplified

not-amplified

0

positive

positive

low

14

infiltrative lobular breast carcinoma

disomic

haematogenous

disomic

not-amplified

not-amplified

0

positive

positive

low

15

infiltrative lobular breast carcinoma

disomic

haematogenous

disomic

not-amplified

not-amplified

0

positive

positive

low

  1. Amplified: >6 or cluster of signals; gains: 3ā€“5 signals.
  2. ER: estrogen receptor, PR: progesteron receptor.