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Figure 2 | Journal of Experimental & Clinical Cancer Research

Figure 2

From: Overexpression of DNA damage-induced 45 α gene contributes to esophageal squamous cell cancer by promoter hypomethylation

Figure 2

A and B show the mean methylation status of each CG pairs in the promoter region upstream of GADD45α gene in tumor tissue and adjacent normal tissue. Compared with adjacent normal tissue, the promoter region with 11 CG pairs (-158,-146,-135,-122,-116,-110,-104,-96,-91,-84, and-64 bp) upstream of GADD45α gene were hypomethylation in tumor tissue. C, the average methylation levels of CpG pairs in the region (-190 to-10 bp) of GADD45α promoter is significantly decreased in tumor tissue compared to the adjacent normal tissue. D shows the global DNA methylation levels of tumor and adjacent normal tissue. Compared with adjacent normal tissue, the global DNA methylation level in tumor tissue is lower.

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