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Figure 2 | Journal of Experimental & Clinical Cancer Research

Figure 2

From: Short-term anti-vascular endothelial growth factor treatment elicits vasculogenic mimicry formation of tumors to accelerate metastasis

Figure 2

Hypoxia is implicated in the adaptive response after short-term bevacizumab treatment. Expression of HIF-1α in pulmonary tumor nodules of the four groups. (A) A representative western blot is shown. β-actin was used as a loading control. (B) While most tumors showed little expression of HIF-1α protein in PBS and cisplatin groups, mice that received bevacizumab and bevacizumab + cisplatin therapy showed a markedly increased level of HIF-1α expression.. *P < 0.05, **P < 0.01.

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