Figure 3

Anti-VEGF treatment induces increased VM. Comparison of VM channels in mice with various treatments. VM channels were positive for PAS staining and negative for CD34 staining in sections (arrow, ×400). (A) PBS (B) bevacizumab (C) cisplatinp and(D) bevacizumab + cisplatin groups. (E) Comparison of VM channels in A, B, C and D. Tumors in the bevacizumab group formed more VM channels than that of PBS and cisplatin, and bevacizumab + cisplatin groups. **P < 0.01.