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Table 1 Relationship between AM expression and clinicopathological features in EOCs

From: Adrenomedullin expression in epithelial ovarian cancers and promotes HO8910 cell migration associated with upregulating integrin α5β1 and phosphorylating FAK and paxillin

Clinicopathological features n AM expression
   - + ++ +++ P value
Age(years)       0.705
< 55 56 5 18 12 21  
≥ 55 40 3 9 9 19  
Histotype       0.155
Serous 75 7 17 17 34  
Non serous 21 1 10 4 6  
Residual tumor after initial laparotomy       0.000*
< 1 cm 42 1 21 10 10  
≥ 1 cm 53 7 6 11 29  
Undetermined 1 0 0 0 1  
Differentiation       0.199
Well-differentiated 27 4 11 6 6  
Moderately-differentiated 23 1 8 3 11  
Poorly-differentiated 39 3 7 11 18  
Undetermined 7 0 1 1 5  
FIGO staging       0.003*
I 17 1 10 1 5  
II 19 0 10 4 5  
III 53 6 7 13 27  
IV 7 1 0 3 3  
Serum CA125       0.301
≥ 500 52 5 11 13 23  
< 500 41 3 16 7 15  
Undetermined 3 0 0 1 2  
  1. *P < 0.05
  2. EOC = epithelial ovarian cancer; AM = Adrenomedullin; FIGO = International Federation of Gynecology and Obstetrics