Figure 5

AOM1 inhibits growth of large tumors in the lung in a NSCLC tumor. A Scid/beige mice were sc implanted with pieces of tumors isolated from lung lesions from Kras^G12D-LSLp53^fl/fl mice. Implanted mice were randomized at 8 days post-implantation and were treated with vehicle, AOM1, carboplatin and combination of both compounds. Tumor volume was measured using caliper twice per week. At terminal analysis whole lung from each mouse was fixed in formalin and was stained in H&E. Representative images from each treatment are shown. In pathology analysis lung lesions were classified into small (less than 10 cells) medium (10-200) and large (more than 200 cells) size and were quantified in each treatment. B Quantifications of lesions in each treatment. Bar graph represents mean number of lesions ± SEM. C Frequency of mice carrying each lesion in each treatment also indicated that AOM1 as single agent or in combination with Carboplatin significantly inhibits percentage of mice carrying large tumors in the lung.