Figure 1

Representative gastric carcinomas showing immunostaining for RKIP predominantly in the cytoplasm, (a), immunostaining for p-MEK predominantly in the cytoplasm (b), and immunostaining for p-ERK in the nucleus and the cytoplasm (c); magnification, 2×. The upper inset shows a surface site of tumour and the lower inset shows a site of deep invasion (a - c); magnification, 40×. Metastatic lymph nodes showing immunostaining for RKIP in the cytoplasm (d), for p-MEK in the nucleus (e), and for p-ERK with strong intensity in the nucleus (f); magnification, 40×. Tumour cells associated with venous invasion showing immunostaining for RKIP with weak intensity (g), for p-MEK (h), and for p-ERK in the nucleus (i); magnification, 40×.