Prognostic value of RKIP and p-ERK in gastric cancer

Table 2 Clinicopathological factors and expression of RKIP, p-MEK, and p-ERK

		cytoplasmic			cytoplasmic			nuclear
		RKIP			p-MEK			p-ERK
	n	negative	positive	p	negative	positive	p	negative	positive	p
Age
> 70	46	16	30	0.43	20	26	0.36	17	29	0.61
≦ 70	59	25	34		31	28		19	40
Gender
female	21	6	15	0.40	15	6	0.036	12	9	0.027
male	84	35	49		36	48		24	60
Histopathology (WHO)
pap	12	3	9	0.20	5	7	0.34	5	7	0.99
tub1	15	2	13		5	10		5	10
tub2	27	11	16		13	14		10	17
por1	14	7	7		5	9		4	10
por2/sig	31	15	16		20	11		10	21
muc	6	3	3		3	3		2	4
Histopathology (2 groups)
differentiated	54	16	38	0.042	23	31	0.21	20	34	0.54
undifferentiated	51	25	26		28	23		16	35
Depth of invasion
T1b/2	32	4	28	< 0.001	14	18	0.51	12	20	0.65
T3/4	73	37	36		37	36		24	49
LN metastasis
negative (N0)	35	8	27	0.028	16	19	0.68	15	20	0.19
positive (N1/2/3)	70	33	37		35	35		21	49
Distant metastasis or recurrence
negative	68	19	49	0.002	33	35	0.99	27	41	0.17
positive	37	22	15		18	19		9	28
Stage
I/II	53	14	39	0.007	24	29	0.50	19	34	0.73
III/IV	52	27	25		27	25		17	35

ISSN: 1756-9966