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Figure 4 | Journal of Experimental & Clinical Cancer Research

Figure 4

From: BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells

Figure 4

Activation of Akt protein involved in BLyS-enhanced cell migration. (A) Decreased number of migrated MDA-MB-435 cells was examined when the cells were treated with API-1 (10 μM) and SB 202190 (5 μM) for 8 h (original magnification 200 ×). Data were means of triplicate samples with ± SD; vs 2% FBS, **, P < 0.01; vs BLyS (10 ng/ml), ###, P < 0.001. (B) Phosphorylation of Akt and p38 MAPK proteins in MDA-MB-435 cells by Western Blotting analysis. (C) MDA-MB-435 cells were challenged with API-1 and SB 202190 for 4 h. API-1 inhibited the BLyS-induced (10 ng/ml) phosphorylation of Akt.

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