Influence of conditioned medium from distinct adipose tissue origins in the proliferation of PC-3 cells. Analyses were performed using conditioned medium of 21 samples of periprostatic (PP) and 10 samples of visceral (VIS) adipose tissue, after explants and stromal-vascular fraction primary cultures. A. Effect of adipose tissue-derived CM on PC-3 cell proliferation, in comparison with control (0% CM) (**P < 0.01 in relation with 0% CM, one-way ANOVA with two-sided post-hoc Dunnett test). B. PC-3 cell proliferation was normalized per gram of adipose tissue and compared according to fat depot and adipose tissue fraction (**P < 0.01 and *** P < 0.0001 between groups, independent samples t-test). CM, conditioned medium; PP, periprostatic; SVF, stromal-vascular fraction; VIS, visceral.