Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro

Table 1 Gelatinase activity in conditioned medium from primary cultures of periprostatic (PP) adipose tissue explants, according to clinical and pathological characteristics

		MMPs activity in supernatant of PP adipose tissue explant cultures (A.U.)
	Demographics	MMP2		MMP9
	n (%)	mean ± S.E.M.	P	mean ± S.E.M.	P
Age at diagnosis, yrs^a
< median (65.1)	13 (52.0)	982.9 ± 154.8	0.591	498.9 ± 71.6	0.624
≥ median (65.1)	12 (48.0)	878.7 ± 111.2		558.3 ± 93.6
BMI, Kg/m^{2 b}
< 25	11 (44.0)	895.4 ± 135.3	0.739	392.1 ± 48.3	0.036
≥ 25	14 (56.0)	960.3 ± 134.4		635.8 ± 87.5
Pathologic status^b
BPH	5 (20.0)	958.6 ± 97.0	0.795	715.5 ± 142.6	0.242
PCa (< pT3)	14 (56.0)	873.8 ± 150.2		461.9 ± 68.1
PCa (≥pT3)	6 (24.0)	1026.2 ± 169.8		511.0 ± 128.0
Gleason grade^a
< 7	8 (40.0)	930.7 ± 189.5	0.967	477.0 ± 94.9	0.987
≥ 7	12 (60.0)	920.7 ± 148.6		479.1 ± 81.7

Results from zymograms performed in supernatants of in vitro culture of PP adipose tissue explants (n = 25). ^a Independent samples t-test or ^b one-way ANOVA; A.U., arbitrary units; S.E.M., standard error of mean. MMP2, matrix metalloproteinase 2; MMP9, matrix metalloproteinase 9. BMI, body mass index. BPH, nodular prostatic hyperplasia; PCa, prostate cancer.

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