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Table 1 Gelatinase activity in conditioned medium from primary cultures of periprostatic (PP) adipose tissue explants, according to clinical and pathological characteristics

From: Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro

   MMPs activity in supernatant of PP adipose tissue explant cultures (A.U.)
  Demographics MMP2   MMP9  
  n (%) mean ± S.E.M. P mean ± S.E.M. P
Age at diagnosis, yrsa      
   < median (65.1) 13 (52.0) 982.9 ± 154.8 0.591 498.9 ± 71.6 0.624
   ≥ median (65.1) 12 (48.0) 878.7 ± 111.2   558.3 ± 93.6  
BMI, Kg/m2 b      
   < 25 11 (44.0) 895.4 ± 135.3 0.739 392.1 ± 48.3 0.036
   ≥ 25 14 (56.0) 960.3 ± 134.4   635.8 ± 87.5  
Pathologic statusb      
   BPH 5 (20.0) 958.6 ± 97.0 0.795 715.5 ± 142.6 0.242
   PCa (< pT3) 14 (56.0) 873.8 ± 150.2   461.9 ± 68.1  
   PCa (≥pT3) 6 (24.0) 1026.2 ± 169.8   511.0 ± 128.0  
Gleason gradea      
   < 7 8 (40.0) 930.7 ± 189.5 0.967 477.0 ± 94.9 0.987
   ≥ 7 12 (60.0) 920.7 ± 148.6   479.1 ± 81.7  
  1. Results from zymograms performed in supernatants of in vitro culture of PP adipose tissue explants (n = 25). a Independent samples t-test or b one-way ANOVA; A.U., arbitrary units; S.E.M., standard error of mean. MMP2, matrix metalloproteinase 2; MMP9, matrix metalloproteinase 9. BMI, body mass index. BPH, nodular prostatic hyperplasia; PCa, prostate cancer.