Figure 3

Representative case 1. A 43-year-old man (Patient 12) affected by a glioblastoma multiforme in the corpus callosum. Cerebral Blood Volume (CBV) map illustrating a section of the lesion before treatment (a); co-registered transverse post-Gd T1-weighted image showing an area of increased contrast enhancement, before treatment (b); CBV map acquired during treatment indicates a decreased blood volume in the region of interest (c); transverse post-Gd T1-weighted image, acquired 7 weeks after the onset of treatment, shows a decrease in contrast enhancement (d). Differential histogram of normalized CBV (nCBV) values inside the volume of interest, before treatment (e) and after a single dose of bevacizumab (f), showing a decrease in both hyper/hypo-perfused subvolumes.