Figure 4

Representative case 2. A 50-year-old man affected by a glioblastoma multiforme in the left temporal region (Patient 10): Cerebral Blood Volume (CBV) map illustrating a section of the lesion before treatment (a); co-registered transverse post-Gd T1-weighted image showing the area of increased contrast enhancement, before treatment (b); normalized CBV (nCBV) map showing the modification of the blood volume after a single dose of bevacizumab (c); co-registered transverse post-Gd T1-weighted image acquired at the first follow-up, showing an augmented area of contrast enhancement and necrosis (d). Differential nCBV histogram inside the volume of interest, before treatment (e) and after a single dose of bevacizumab (f), showing a decrease in the hyper-perfused regions but an increase in the hypo-perfused sub-volumes.