Figure 5

GRP78 knockdown decreased JNK and ERK signaling pathway. (A) Western blot analysis of JNK and p-JNK levels in cells that stably expressing shGRP78-3. (B) Western blot analysis of the ERK and p-ERK levels in cells that stably expressing shGRP78-3. (C) Western blot analysis of FAK, pY397-FAK, Src and pY416-Src in the cells that stably expressing shGRP78-3. All the experiments were repeated for three times, the results of quantative analysis were represented as $\overline{x}$± SE and analyzed by one-way ANOVA. (Columns,mean of three separate experiments; bars, SE; *, values significantly different at the 5% levels).