Bevacizumab inhibits the growth of bone metastasis prostate cancer cell line C4-2B. a. Different concentrations of bevacizumab inhibited the cell proliferation of C4-2B in a dose-dependent manner after 2-day incubation determined by mitochondrial MTS assay. Ig G (100 μg/ml) did not decrease the growth of C4-2B. cells. VEGF (100 ng/ml) enhanced the growth of C4-2B cells. b. The effect of bevacizumab on the inhibitory proliferation of C4-2B was gradually increased with a time-dependence. The relative fold was assigned as 1.0 in the absence of bevacizumab treatment. **means P < 0.01, significant differences from the bevacizumab treated with untreated group.