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Figure 1 | Journal of Experimental & Clinical Cancer Research

Figure 1

From: Lysosomal Membrane Permeabilization is an Early Event in Sigma-2 Receptor Ligand Mediated Cell Death in Pancreatic Cancer

Figure 1

Structures. Sigma-2 receptor ligands SW43 and SW120, derivatives of N-(9-(6-aminohexyl)-9-azabicyclo[3.3.1]nonan-3α-yl)-N-(2-methoxy-5-methylphenyl) carbamate hydrochloride (SV119), and PB282 and PB385, derivatives of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)propyl]-piperazine dihydrochloride (PB28). Affinity to sigma-1/2 (σ2) receptor given by Ki (nM).

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